- A-Z
- Endocytobiosis and ...
- Volume 29
- Identification of a...
- Autor(in)
- Seitenbereich
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024-029
- Schlagwort(e)
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Albanian population, CYP2C19, CYP2C9, allele, genotype
- Zusammenfsg.
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Cytochrome P450 enzymes are a superfamily of heme-proteins which are involved in drug metabolism. There is an association between CYP450 genetic variants, patient’s response to drug therapy, adverse drug reactions and therapeutic failures. This study aims to determine the frequency of CYP2C9*2 and CYP2C19*2 alleles and to predict the frequency of poor metabolizers in Albanian healthy population for CYP2C9 and CYP2C19 genes. Genotypes were determined for 100 healthy Albanian individuals, randomly selected from different regions of Albania. The analysis of the most common allelic variants, CYP2C9*2 and CYP2C19*2, were performed by PCR-RFLP analyses. For CYP2C9 the frequency of C9*2 allele was 14.5% and 2% of the subjects were predicted to be poor metabolizers. For CYP2C19 the frequency of C19*2 allele was 21%, and 4.4% of subjects were predicted to be poor metabolizers. These results indicate a particular distribution pattern of CYP2C9*2 and CYP2C19*2 alleles in Albanian population, which is most valuable in predicting the frequency of Albanian patients classified as poor metabolizers of common drugs such as clopidogrel and warfarin.