The chloroplast and mitochondrion genomes encode proteins important for organellar processes such as photosynthesis, respiratory chain activity, and gene expression. Expression of organellar genes is regulated by numerous nuclear-encoded proteins involved in many posttranscriptional steps: RNA processing, editing, splicing, stabilization, and translation. Many of these proteins are sequence-specific RNA-binding factors which are thought to recruit enzymes and lead them to the RNA target site rather than having enzymatic activity themselves. Here, we summarize the data of our recent research on global and specific nuclear-encoded factors involved in organellar RNA metabolism in a general context.