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195 - 210
- Zusammenfsg.
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The application of spores from Clostridium oncolyticum M 55, ATCC 13 732 (10(8) spores in 0,1 mi i.v.) and xenogenic antitumor substances (0,2 mg/0,5 ml/day x 8, i.m.) were found to be inhibiting in vivo the local recurrence and liver metastasis, when applied in conjunction with the surgical removal of the primary tumor. The survival time of mice to which Clostridium oncolyticum M 55 with antitumor substances was administered was significantly prolonged when compared with that of mice treated by injection of methylcholanthrene (MCA) alone. Furthermore the incidence of the local recurrence of tumors and liver metastasis was significantly lower in mice treated with Clostridium oncolyticum M 55 spores plus xenogenic peptides and proteins compared to other experimental groups. Also the mean survival time in groups of mice which showed no liver metastasis was significantly prolonged in those animals treated with spores plus xenogenic antitumoral substances. Impulse cytophotometric measurement of the DNA content of cell nuclei has been used in an attempt to illustrate the objective and quantitative characteristics of metastasis tissue and the assessment of cell growth and degree of abnormality. The antitumoral activity of symbiogenetic interactions of microorganisms is probably due to the effects of bacterial collagenase enzymes on tumor cells excreted by the clostridial vegetative cells, to the reactivity of tumor angiogenesis factor (TAF) through tumor cells and the transmission of other stimuli of at yet unknown biochemical nature to the host. The bacterial effect is enhanced by the xenogenic antitumor agent, which stimulating acts on the body's own immune resistance against tumor tissue cells.
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